ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Pediatr Diabetes. 2020;21(3):456–459.For many years, infections have been thought to trigger the onset of type 1 diabetes (T1DM) or even to be one of the causes of autoimmune processes that eventually lead to the destruction of the pancreatic beta-cell. In particular, maternal rubella virus infections during pregnancy are reported to increase the risk of T1DM in children, and fetal rubella infection leads to highe...

To read the full abstract: Sci Rep. 2019 Jun 13;9(1):7727As outlined in paper 10.1, intrauterine and early neonatal infections with a number of viruses are thought to contribute to the incidence of type 1 diabetes (T1DM) later in life. Amongst the viruses to be considered, enteroviruses have been found to be the most important. It is therefore important to know whether vaccination against enteroviruses would reduce the incidence of autoimmune di...

Pediatr Diabetes. 2018 May 15. doi: 10.1111/pedi.12691There is a small but significant debate as to whether or not type 1 (T1D) and type 2 diabetes (T2D) are the same disease with albeit different course. It might therefore be prudent to include into a chapter on T1D a publication on T2D. This study aimed to describe recent medication patterns and changes in medication patterns and glycemic con...

Brief summary: This 12-months randomized, controlled, phase 3 study compared the efficacy and safety of once-weekly Somatrogon 0.66 mg/kg/week with once-daily somatropin in prepubertal children with GHD. The efficacy of once-weekly Somatrogon was noninferior to once-daily somatropin, with similar safety and tolerability profiles.Somatrogon (MOD-4023) is a long-acting rhGH recently approved by the European Medicines Agency for the treatment of children wi...

To read the full abstract: N Engl J Med. 2019 Oct 24;381(17):1644-1652. doi: 10.1056/NEJMoa1813279.This remarkable case report - by authors from Boston Children’s Hospital and funded by Mila’s Miracle Foundation - describes the development and use of a patient-customised antisense oligonucleotide drug that was tailored specifically against the unique DNA sequence mutation in a 6-ye...